Delivering clinically proven epigenetically programmed memory T Cells to fight cancer
Reprogramming T Cells for extensive coverage of solid tumors with long-lasting immunoprotection, including common and rare types.
Mongoose Bio is an early-stage clinical company revolutionizing the delivery of T cell precision therapies against common and rare solid tumors. Mongoose Bio has developed a unique and disruptive approach to adoptive T cell therapies using epigenetic reprogramming of autologous Tcm cells harboring defined TCRs against empirically-validated, highly-immunogenic tumor targets to generate active and persistent TCR-T therapeutics. This approach has several distinct advantages:
- Reprogrammed central memory T cells (Tcm) offer a significant opportunity to minimize toxicity, accommodate outpatient-based treatments and innovative combination strategies;
- Reprogrammed Tcm are differentiated from TIL and CAR-T products that typically rely on terminally differentiated Teff and Tex cells that have reduced regenerative capacity, are rarely persistent, and only display limited efficacy.
Our mission is to create the ultimate individualized T cell-based therapy for cancer, offering the prospect of treating all cancers by targeting tumor antigens with ex-vivo expanded T cells.
programmed memory
TCR-T cells
Revolutionizing
the treatment
of cancer
Scientific Objective
Our objective is to revolutionize adoptive T cell therapies by the epigenetic reprogramming of Tcm cells harboring TCRs against highly immunogenic autochthonous tumor specific targets to create long-lived efficacious TCR-T cell therapies that will eradicate common and rare solid tissue malignancies.
Mongoose Bio | CAR-T, TCR-T, TIL Therapies | |
Number of Targets | Many | Few |
Target Location | Extracellular or Intracellular | Extracellular (CAR-T) |
Persistence and Activity | High | Low |
Antigen Loss | Low | High |
Serious Toxicities | Low | High |
High-dose Lymphodepletion | Not Required | Required |
Combination Strategies | Easily Implemented | Problematic |
History
Backed by 20 years of research in TCR target identification and the epigenetics of T cell memory, Mongoose Bio has developed a stable of four novel, highly immunogenic targets that are relatively unchartered in the treatment of cancer. The Company has also developed a proprietary technology that extends the life of memory T cells explicitly modified to kill targeted tumor cells over a sustained period of time. Solving for the lack of novel targets and the inability of T cells to persist over time, Mongoose Bio is positioned uniquely among oncology focused therapeutic companies.